BMJ : British medical journal

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• BMJ · Feb 2004

  Randomized Controlled Trial Multicenter Study Clinical Trial

  Effects of low dose ramipril on cardiovascular and renal outcomes in patients with type 2 diabetes and raised excretion of urinary albumin: randomised, double blind, placebo controlled trial (the DIABHYCAR study).

  To investigate whether a low dose of the angiotensin converting enzyme (ACE) inhibitor ramipril lowers cardiovascular and renal events in patients with type 2 diabetes who have microalbuminuria or proteinuria. ⋯ Low dose (1.25 mg) ramipril once daily has no effect on cardiovascular and renal outcomes of patients with type 2 diabetes and albuminuria, despite a slight decrease in blood pressure and urinary albumin. The cardiovascular benefits of a daily higher dose (10 mg) ramipril observed elsewhere are not found with an eightfold lower daily dose.

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• BMJ · Feb 2004

  Review

  Where is the evidence that animal research benefits humans?

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• BMJ · Feb 2004

  Drug regulators study global treaty to tackle counterfeit drugs.

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• BMJ · Feb 2004

  Comment Letter

  Reconfiguration of surgical, emergency, and trauma services: recommendations are useful for configuring emergency services in the developing world.

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• BMJ · Feb 2004

  Australia's contribution to global health fund provokes dismay.

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