BMJ : British medical journal
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To determine the benefits and harms of medical cannabis and cannabinoids for chronic pain. ⋯ Moderate to high certainty evidence shows that non-inhaled medical cannabis or cannabinoids results in a small to very small improvement in pain relief, physical functioning, and sleep quality among patients with chronic pain, along with several transient adverse side effects, compared with placebo. The accompanying BMJ Rapid Recommendation provides contextualised guidance based on this body of evidence. SYSTEMATIC REVIEW REGISTRATION: https://osf.io/3pwn2.
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To investigate the efficacy, acceptability, and safety of muscle relaxants for low back pain. ⋯ PROSPERO CRD42019126820 and Open Science Framework https://osf.io/mu2f5/.
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To determine and compare the effects of drug prophylaxis on SARS-CoV-2 infection and covid-19. ⋯ This article is a living systematic review that will be updated to reflect emerging evidence. Updates may occur for up to two years from the date of original publication.
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To compare effect estimates of randomised clinical trials that use routinely collected data (RCD-RCT) for outcome ascertainment with traditional trials not using routinely collected data. ⋯ Randomised clinical trials using routinely collected data for outcome ascertainment show smaller treatment benefits than traditional trials not using routinely collected data. These differences could have implications for healthcare decision making and the application of real world evidence.
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Meta Analysis
Efficacy and safety of antidepressants for the treatment of back pain and osteoarthritis: systematic review and meta-analysis.
To investigate the efficacy and safety of antidepressants for back and osteoarthritis pain compared with placebo. ⋯ PROSPERO CRD42020158521.