Journal of anesthesia
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Journal of anesthesia · Jan 2006
Effects of AM281, a cannabinoid antagonist, on circulatory deterioration and cytokine production in an endotoxin shock model: comparison with norepinephrine.
The purpose of this study was to examine the comparative effects of AM281, a cannabinoid antagonist, and norepinephrine (NE) on systemic hemodynamics, and renal and mesenteric artery blood flow in an endotoxin shock model. ⋯ Although NE and AM281 both prevented endotoxin-induced deterioration of systemic hemodynamics, AM281 yielded better preservation of mesenteric blood flow and attenuation of cytokine production than NE.
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Journal of anesthesia · Jan 2006
Randomized Controlled Trial Clinical TrialEffects of landiolol on hemodynamic response and seizure duration during electroconvulsive therapy.
This study was done to evaluate the effect of landiolol, an ultra-short-acting beta-blocker, on the hemodynamic response and the duration of seizure activity during electroconvulsive therapy (ECT). ⋯ As the landiolol dose of 0.2 mg x kg(-1) caused shorter seizure duration, and because the hemodynamic effects after ECT of the 0.1 mg x kg(-1) and 0.2 mg x kg(-1) doses were similar, it was concluded that a 0.1 mg x kg(-1) landiolol bolus was the appropriate dose pretreatment before ECT.
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Journal of anesthesia · Jan 2006
Randomized Controlled TrialDexmedetomidine during local anesthesia.
The objective of our study was to assess the efficacy and safety of dexmedetomidine given in a small dose for a 1-h infusion as an adjuvant to local analgesia in ophthalmic operations. The study was double-blind prospective, randomized, and placebo controlled. We studied the effects of a small dose of dexmedetomidine (0.5 micro.kg(-1).h(-1) for 10 min followed by 0.2 micro.kg(-1).h(-1) for 50 min. ⋯ Bispectral index values were significantly lower in the dexmedetomidine group than the placebo group. Also, intraocular pressure significantly decreased in the dexmedetomidine group compared to the placebo group. The study revealed that dexmedetomidine in the studied dose has a sedative effect, provides safe control of heart rate and blood pressure, and also decreases intraocular pressure during ophthalmic surgery under local anesthesia.
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Journal of anesthesia · Jan 2006
Randomized Controlled TrialOmission of fentanyl during sevoflurane anesthesia decreases the incidences of postoperative nausea and vomiting and accelerates postanesthesia recovery in major breast cancer surgery.
Our purpose was to investigate the effect of omission of fentanyl during sevoflurane anesthesia on the incidences of postoperative nausea and vomiting and on postanesthesia recovery in female patients undergoing major breast cancer surgery. ⋯ Omission of fentanyl during sevoflurane anesthesia, combined with diclofenac and local infiltration anesthesia, decreases the incidences of postoperative nausea and vomiting and accelerates postanesthesia recovery in patients undergoing major breast cancer surgery.
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Journal of anesthesia · Jan 2006
Case ReportsChanges on MRI in lumbar disc protrusions in two patients after intradiscal electrothermal therapy.
We examined changes to the protruded lumbar disc after intradiscal electrothermal therapy (IDET) using magnetic resonance imaging (MRI) in two patients with chronic discogenic low back pain who underwent IDET. MRI was performed before and 6 months after the treatments. In the follow-up MRI studies, the protrusions were almost abolished and normalized in both patients. We thus confirmed shrinkage of the protruded disc by IDET on MRI images in two patients.