Journal of anesthesia
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Journal of anesthesia · Jan 2006
Randomized Controlled TrialEffects of a protease inhibitor, ulinastatin, on coagulation and fibrinolysis in abdominal surgery.
Ulinastatin is well known to inhibit the activity of polymorphonuclear leukocyte elastase (PMNE). The PMNE concentration correlates with the activities of coagulation and fibrinolysis. The purpose of the present study was to investigate the effects of ulinastatin, a protease inhibitor, on coagulation and fibrinolysis in abdominal surgery. ⋯ Ulinastatin could inhibit coagulation and fibrinolysis in abdominal surgery.
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Journal of anesthesia · Jan 2006
Case ReportsAberrant halt of syringe pump motion: an improved system to prevent false setting of the syringe.
A syringe pump is used to inject precise doses of drugs having a strong action; for example, vasoactive drugs. Unexpected and undetected halt of a syringe pump can lead to potentially life-threatening complications. We experienced a sudden halt in the movement of a syringe pump (Terufusion syringe pump; Terumo, Tokyo, Japan) in two patients while administering norepinephrine in the intensive care unit (ICU). ⋯ Once we had determined how a false setting of the syringe could occur without the syringe pump giving off an alarm from the onset, we collaborated with the Terumo Company to revise their current instruction manual to incorporate this as a warning. We also helped in the development of a new model, including a new safety feature that would prevent a false setting of the syringe from occurring at all. This new model was released in December 2003.
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Journal of anesthesia · Jan 2006
Anandamide absorption by direct hemoperfusion with polymixin B-immobilized fiber improves the prognosis and organ failure assessment score in patients with sepsis.
Direct hemoperfusion (DHP) with polymixin B-immobilized fiber (PMX) has been reported to be effective for patients with septic shock. The aim of this study was to clarify the mechanism of PMX-DHP effect on septic shock. ⋯ ANA, an intrinsic cannabinoid that induces hypotension in septic shock, is inferred to be the main mechanism of the PMX-DHP effect. Removal of ANA by PMX-DHP could be key to successful septic shock treatment.
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Journal of anesthesia · Jan 2006
Clinical TrialRectal luminal Pr(CO2), measured by automated air tonometry, does not reflect gastric luminal Pr(CO2) in children.
Rectal luminal regional P(CO2) (Pr(CO2)) was compared with gastric luminal Pr(CO2) measured by automated air tonometry at intervals of 10 min in 20 children aged 6-16 years scheduled for elective surgery under general anesthesia. In 5 patients, measurement of rectal Pr(CO2) failed because of catheter-related problems. In the remaining 15 children, aged 10.6 +/- 2.5 years, 19 +/- 7 paired rectal and gastric Pr(CO2) values (n total, 241) were measured. ⋯ In patients with obvious feces in the rectum, bias (precision) for gastric compared to rectal Pr(CO2) was -2.7 kPa (2.6 kPa) and in those with empty rectum, -0.75 kPa (1.42 kPa; t-test; P < 0.001). Based on our in vivo data, rectal luminal Pr(CO2), measured by automated air tonometry, does not reflect gastric luminal Pr(CO2) in children. Enteral luminal gas production within feces in the rectum seems to be a major source of this disagreement.
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Journal of anesthesia · Jan 2006
Case ReportsProlonged relaxant effects of vecuronium in patients with deliberate hypermagnesemia: time for caution in cesarean section.
We present two cases showing significantly prolonged action of vecuronium from magnesium treatment after general anesthesia for urgent cesarean section. The serum magnesium levels were maintained at a therapeutic range for severe eclampsia in one patient (5.6 mg.dl(-1)) and for tocolysis in another with placenta previa totalis (6.9 mg.dl(-1)). ⋯ As a result, the patients received prolonged mechanical ventilation. Our cases underscore the need for anesthesiologists as well as obstetricians to be aware of the prolongation of the action of nondepolarizing muscle relaxants as a result of magnesium treatment.