Journal of anesthesia
-
Journal of anesthesia · Jan 2009
Randomized Controlled TrialEffects of intravenous adenosine 5'-triphosphate on intraoperative hemodynamics and postoperative pain in patients undergoing major orofacial surgery: a double-blind placebo-controlled study.
We conducted a double-blind placebo-controlled study to investigate the effects of the intraoperative intravenous infusion of adenosine 5'-triphosphate (ATP) on intraoperative hemodynamics and postoperative pain in patients undergoing major orofacial surgery. ⋯ Our data suggest that intraoperative ATP infusion can blunt hemodynamic responses to surgical stimuli and produce prolonged analgesia in patients undergoing major orofacial surgery.
-
Journal of anesthesia · Jan 2009
Randomized Controlled Trial Comparative StudyHyperventilation versus standard ventilation for infants in postoperative care for congenital heart defects with pulmonary hypertension.
In infants undergoing surgery for cardiac defects with left-to-right shunt, a hyperventilation strategy has been applied to prevent pulmonary hypertensive crisis (PHC). Hyperventilation with a large tidal volume and/or higher airway pressure, however, may be detrimental to the lung. This randomized study compared the effects of hyperventilation versus standard ventilation. ⋯ Hyperventilation may cause lung injury and systemic inflammation in infants with pulmonary hypertension undergoing corrective heart surgery.
-
Journal of anesthesia · Jan 2009
Randomized Controlled TrialPostoperative analgesic effect of preoperative intravenous flurbiprofen in arthroscopic rotator cuff repair.
This study was carried out to evaluate the postoperative analgesic effects of preoperative intravenous flurbiprofen in patients undergoing arthroscopic rotator cuff repair under general anesthesia. ⋯ These results show that preoperative intravenous flurbiprofen facilitates the analgesic effect in the early postoperative period after arthroscopic rotator cuff repair.
-
Journal of anesthesia · Jan 2009
Randomized Controlled Trial Comparative StudyIsoflurane and sevoflurane decrease entropy indices more than halothane at equal MAC values.
Recently, bispectral index (BIS) values were demonstrated to be different for various anesthetics as a result of differential effects on electroencephalographic (EEG) signals. Entropy is similar to the BIS monitor, as both process raw EEG to derive a number. We hypothesized that entropy may also be anesthetic agent-specific. ⋯ During the study period, for a given MAC value, both RE and SE remained low in the isoflurane and sevoflurane groups compared to the halothane group. For a given MAC, the RE and SE were comparable during wash-in and wash-out phases. Halothane produced higher entropy values as compared to isoflurane and sevoflurane at equivalent MAC levels.
-
Journal of anesthesia · Jan 2009
Randomized Controlled TrialPreoperative fluid and electrolyte management with oral rehydration therapy.
We hypothesized that oral rehydration therapy using an oral rehydration solution may be effective for preoperative fluid and electrolyte management in surgical patients before the induction of general anesthesia, and we investigated the safety and effectiveness of oral rehydration therapy as compared with intravenous therapy. ⋯ The results suggest that the oral rehydration therapy with an oral rehydration solution before surgery is superior to the current preoperative intravenous therapy for the provision of water, electrolytes, and carbohydrates, and this therapy should be considered as an alternative to the intravenous therapy for preoperative fluid and electrolyte management in selected surgical patients in whom there is no reason to suspect delayed gastric emptying.