Journal of anesthesia
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Journal of anesthesia · Feb 2012
ReviewAdditive diuretic response of concurrent aminophylline and furosemide in children: a case series and a brief literature review.
Aminophylline exerts a renovascular effect, acting by adenosine receptor blockade or type IV phosphodiesterase inhibition. Clinically, these drugs have been used with furosemide to induce diuresis in adults and neonates. ⋯ No side effects were evident. Administration of aminophylline at low doses (3 mg/kg) successfully promoted increased urine output over the 6-h study period in all four children.