Journal of anesthesia
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Journal of anesthesia · Oct 2021
Randomized Controlled TrialEffect of chlorpheniramine administration on postoperative catheter-related bladder discomfort in patients undergoing transurethral excision of bladder tumor: a prospective randomized study.
Catheter-related bladder discomfort (CRBD) is postoperative distress caused by a urinary catheter. CRBD is related to muscarinic receptor activation. Chlorpheniramine has antimuscarinic properties. Hence, this investigation was undertaken to evaluate the efficacy of chlorpheniramine in preventing CRBD in patients undergoing transurethral resection of bladder tumor (TURBT). ⋯ Chlorpheniramine administration significantly reduces the incidence and severity of CRBD in the patients undergoing TURBT.