Journal of anesthesia
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Journal of anesthesia · Jan 2006
Case ReportsPostoperative airway obstruction after airway tumor debulking.
Postoperative airway obstruction is a relatively common complication after anesthesia, occurring most often after head and neck surgery. We present a case of postoperative airway obstruction in a patient who underwent airway tumor debulking. This case demonstrates that, in high-risk patients, despite the traditional methods of determining eligibility for extubation, postoperative airway obstruction can still occur, and alternative means of extubation should be considered.
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Journal of anesthesia · Jan 2006
Effect of Ono-EI-600 elastase inhibitor on high-tidal-volume-induced lung injury in rats.
We tested the effect of Ono-EI-600, an elastase inhibitor that suppresses cytokine release, on ventilator-induced lung injury in a rat model. After Wistar rats (aged 8-11 weeks) were anesthetized and tracheostomized, they were randomly assigned to four groups: high tidal volume (V(T)) group (H group: n = 10) receiving peak inspiratory pressure (PIP) 30 cmH(2)O for 240 min; high V(T) with drug group (HD group: n = 10) receiving the same ventilation settings as H group and also intravenous infusion 10 mg x kg(-1) x h(-1) of Ono-EI-600 during the protocol; the lower V(T) group (L group: n = 5) receiving PIP 10 cmH(2)O for 240 min; and control group (C group: n = 5) receiving the same ventilation as L group for 30 min. ⋯ However, for the H and HD groups, no differences were found in arterial blood gas data, cytokine levels in BALF, and histological injury scores. Our experiment provided no evidence that elastase inhibitor Ono-EI-600 protects against lung injury induced by high V(T) ventilation.