Journal of anesthesia
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Journal of anesthesia · Jun 1994
Relationship between cardiac output and mixed venous-arterialPCO 2 gradient in sodium bicarbonate-treated dogs.
We examined the relationship between cardiac output (CO) and mixed venous-arterialPCO 2 gradient ([Formula: see text]) along with the other variables derived from arterial and/or mixed venous blood gases in sodium bicarbonate-treated dogs. Six dogs with low cardiac output following cardiopulmonary resuscitation were used. CO, blood gases, and hemoglobin measurements were repeated every 20-30 min after administration of sodium bicarbonate or normal saline. ⋯ Arteriovenous oxygen content difference ([Formula: see text]), mixed venous oxygen saturation ([Formula: see text]), and[Formula: see text] were highly correlated with CO. The correlation coefficients between[Formula: see text],[Formula: see text], and[Formula: see text] werer=-0.81 (P<0.001),r=0.70 (P<0.001), andr=-0.77 (P<0.001), respectively. The results suggest that, if[Formula: see text] is measured during the steady state, except for the period during the transient increase in CO2 elimination just after the administration of sodium bicarbonate,[Formula: see text] can be used as an index of systemic perfusion even after the administration of sodium bicarbonate.
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Journal of anesthesia · Jun 1994
Textbook of anesthesia on electronic media: trial version as a free software.
The author has compiled a textbook of anesthesia on a floppy diskette and has made it available as free software. It is called "KSAP", which stands for "Knowledge Source for Anesthesia Practice". He aims to create a new form of textbook that is appropriate for current technology. ⋯ The entire book consists of approximately 500 text files, all of which were written by this author. All that is required to use this textbook is an MS-DOS computer and software which reads ASCII text files. Individual files are all simple text files.
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Journal of anesthesia · Jun 1994
Effects of combined intravenous nicardipine and diltiazem administration on the circulatory response to laryngoscopy and tracheal intubation.
To evaluate the effect of combined intravenous administration of the calcium antagonists, nicardipine and diltiazem, on the circulatory responses to tracheal intubation, the mean arterial pressure (MAP) and rate pressure product (RPP) in response to laryngoscopy following tracheal intubation were compared in patients receiving saline placebo or nicardipine 10 μg·kg-1 and diltiazem 0.1 mg·kg-1 60 s before the initiation of laryngoscopy. Each group was comprised of ten patients undergoing elective surgery. The patients receiving saline showed a significant increase in MAP and RPP associated with tracheal intubation. However, these increases were significantly attenuated (P<0.05) in the patients to whom nicardipine and diltiazem were administered concurrently.
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Journal of anesthesia · Jun 1994
Effects of double administration of nicardipine of the cardiovascular response to tracheal intubation in hypertensive patients.
The efficacy of intravenous nicardipine in attenuating the cardiovascular responses to laryngoscopy and tracheal intubation was studied in 20 hypertensive patients. Ten patients received intravenous 1 mg of nicardipine 1 min before induction (N1 group). ⋯ In the N2 group, arterial pressure did not increase but heart rate increased more than that in N1 group. There was no significant difference in rate pressure product between the two groups.
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Journal of anesthesia · Jun 1994
Differential effects of isoflurane, halothane, and ketamine on the regional methionine-enkephalinlike immunoreactivity in the mouse brain.
The widely used measurement index for anesthetic potency, minimum alveolar concentration (MAC), is hypothesized to be the sum of the effects on multiple neural systems whose contribution to anesthesia differs depending on the agents used. The present study, which compared the effects of halothane, isoflurane, and ketamine, at equipotent level of anesthesia, on the methionine-enkephalinergic neurons in 9 brain regions, showed a significant difference in the methionine-enkephalin-like immunoreactivity (Met-ENK-like IR) among the anesthetics in each region. The order of the Met-ENK-like IR was: halothane > ketamine > isoflurane in the caudatus putamen; halothane > isoflurane ≊ketamine in the nucleus accumbens and the ventral pallidum; halothane ≊isoflurane > ketamine in the globus pallidus, the nucleus dorsomedialis hypothalami, and the nucleus ventromedialis hypothalami; and halothane > isoflurane > ketamine in the arcuate nucleus, the periaqueductal gray, and the nucleus reticularis parvocellularis. These findings indicate that these three anesthetics affect the methionine-enkephalinergic neurons in the motor and pain controlling pathways in different fashions.