Der Schmerz
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Meta Analysis Comparative Study
Meta-analysis of dropout rates in randomized controlled clinical trials: opioid analgesia for osteoarthritis pain.
The interpretation of opioid studies in patients with chronic pain due to osteoarthritis is limited by a high dropout rate. Therefore, the implication of dropouts on the recommendation of opioids in chronic osteoarthritis pain was analyzed. ⋯ In spite of analgesic effects, many osteoarthritis patients prefer to stop chronic opioid use, because of adverse events. Therefore, opioids are not generally recommended in osteoarthritis.