Der Schmerz
-
Pain has a complex pathophysiology that is expressed in multifaceted and heterogeneous clinical phenotypes. This makes research on pain and its treatment a potentially data-rich field as large amounts of complex data are generated. Typical sources of such data are investigations with functional magnetic resonance imaging, complex quantitative sensory testing, next-generation DNA sequencing and functional genomic research approaches, such as those aimed at analgesic drug discovery or repositioning of drugs known from other indications as new analgesics. ⋯ In addition, knowledge discovery in big data accessible in electronic knowledge bases, can be used to generate hypotheses and to exploit the accumulated knowledge about pain for the discovery of new analgesic drugs. This enables so-called data-information-knowledge-wisdom (DIKW) approaches to be followed in pain research. This article highlights current examples from pain research to provide an overview about contemporary data scientific methods used in this field of research.
-
The effect of integrating clinical pharmacists in German palliative care units with regard to the quality of drug therapy and drug costs has yet not been evaluated. ⋯ The results indicate that the integration of a clinical pharmacist is well suited to optimizing the interprofessional treatment of distressing symptoms with a beneficial economic outcome in palliative care. Consequently, the permanent integration of a clinical pharmacist on an inpatient palliative care unit seems to be beneficial and advisable.
-
The treatment of patients with chronic pain should be carried out in interdisciplinary multimodal pain programs of which relaxation methods represent an integral part. The German disease management guidelines (NDGM) on nonspecific low back pain currently do not recommend biofeedback as a relaxation technique for chronic low back pain due to inadequate data. Furthermore, health insurances do not cover the costs of this treatment. ⋯ Biofeedback relaxation is a suitable method in the treatment of chronic non-specific low back pain. Its use in interdisciplinary multimodal pain programs should be encouraged.