Respiratory medicine
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Respiratory medicine · Dec 2012
Review Meta AnalysisIndacaterol therapy in patients with COPD not receiving other maintenance treatment.
Recent findings of rapid lung function decline in younger patients with moderate COPD severity suggest the need for effective early treatment. ⋯ Indacaterol, given to patients with moderate-to-severe COPD not receiving other maintenance treatments, provided effective bronchodilation with significant, clinically relevant improvements in dyspnoea and health status compared with placebo.
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Respiratory medicine · Dec 2012
Multicenter StudyThe burden of chronic obstructive pulmonary disease in the Middle East and North Africa: results of the BREATHE study.
COPD is a progressive pulmonary disease which may have a profound impact on general health status and quality of life. This article presents data on the burden of COPD obtained from the BREATHE study in the Middle East, North Africa and Pakistan. This study was a large general population survey of COPD conducted in eleven countries of the region using a standardised methodology. ⋯ Psychological distress was reported by between 42.3% and 53.2% of subjects, depending on the item. In conclusion, the burden of COPD is important, and covers central aspects of daily life. For this reason, physicians should take time to discuss it with their patients, and ensure that the management strategy proposed addresses all their needs.
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Respiratory medicine · Dec 2012
Randomized Controlled TrialWalking exercise response to bronchodilation in mild COPD: a randomized trial.
Patients with mild chronic obstructive pulmonary disease (COPD) present abnormal ventilatory mechanics during exercise and may require bronchodilator therapy. However, bronchodilation does not enhance cycling exercise tolerance in these patients whereas walking may be more sensitive to the effects of bronchodilation. ⋯ Bronchodilation did not improve walking endurance in patients with mild COPD despite small physiological benefits of uncertain clinical relevance.
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Respiratory medicine · Dec 2012
Randomized Controlled TrialAssessing efficacy of indacaterol in moderate and severe COPD patients: a 12-week study in an Asian population.
This post hoc analysis evaluated the efficacy of indacaterol, a novel inhaled once-daily long-acting β(2)-agonist, by disease severity (GOLD 2005) in patients with moderate-to-severe COPD from six Asian countries/areas (Hong Kong, India, Japan, Korea, Singapore, Taiwan). ⋯ NCT00794157.
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Respiratory medicine · Dec 2012
Clinical TrialShort term and long term effects of pulmonary rehabilitation on physical activity in COPD.
The central purpose of pulmonary rehabilitation is to reduce morbidity by improving functional capacity through exercise. It is still unknown if improvements in functional capacity are maintained in the long-term and if this leads to increased physical activity levels as measured by a free-living activity monitor. The hypothesis of this study was that pulmonary rehabilitation would lead to a sustained increase in standard outcome measures and in daily physical activity. ⋯ These findings show that while pulmonary rehabilitation increased exercise capacity this was not transmitted into increased daily physical activity. Hence, alternative methods to alter/affect behavioural change need to be addressed.