Journal of neurosurgical anesthesiology
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J Neurosurg Anesthesiol · Oct 2010
Randomized Controlled TrialDoes nitrous oxide affect bispectral index and state entropy when added to a propofol versus sevoflurane anesthetic?
In earlier studies, nitrous oxide (N2O) did not affect bispectral index (BIS) or state entropy (SE) when administered as the sole anesthetic agent. We investigated the effect of adding N2O to sevoflurane or propofol anesthesia on BIS and SE. ⋯ N2O decreased both BIS and SE when added to sevoflurane, but not propofol. The observed changes in the sevoflurane group were not clinically significant. Decreases in BIS and SE in the sevoflurane group could result from a true additive effect and second-gas effect of N2O that was unaccounted for despite a meticulous titration of sevoflurane using end-tidal gas monitoring.
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J Neurosurg Anesthesiol · Oct 2010
Randomized Controlled TrialNeuromonitoring in carotid surgery: are the results obtained in awake patients transferable to patients under sevoflurane/fentanyl anesthesia?
Diagnostic accuracy studies of neuromonitoring devices during carotid endarterectomy in awake patients are limited by the question of the transferability to anesthetized patients. This study was designed to compare the different neuromonitoring parameters in patients under regional and general anesthesia with stump pressure as the primary endpoint and the courses of cerebral blood flow velocity (Vmca) measured by transcranial Doppler sonography, regional cerebral oxygen saturation (rSO2) measured by near-infrared spectroscopy, and the amplitude of somatosensory evoked potentials (SEP) as the secondary endpoints. ⋯ Carotid artery clamping leads to similar results of stump pressure and similar relative changes of transcranial Doppler sonography, near-infrared spectroscopy, and SEP monitoring in patients under regional and sevoflurane/fentanyl anesthesia.