Journal of neurosurgical anesthesiology
-
J Neurosurg Anesthesiol · Oct 2013
Clonidine induces sedation through acting on the perifornical area and the locus coeruleus in rats.
The main target site of action for the sedative clonidine (CLO), an α2 adrenoceptor agonist, has been considered to be the locus coeruleus (LC). However, previous reports suggest other sites of action of CLO than the LC. Our previous studies suggested that the neuronal activities in the perifornical area (Pef) could influence the sedative or the anesthetic level induced by anesthetics. Therefore, we examined whether microinjection of CLO into the Pef might induce sedation in rats. ⋯ The Pef and the LC are responsible for the sedative action of CLO in rats.
-
J Neurosurg Anesthesiol · Oct 2013
Comparative StudyInfluence of Beach Chair Position on Cerebral Oxygen Saturation: A Comparison of INVOS and FORE-SIGHT Cerebral Oximeter.
Although beach chair position (BCP) is frequently used for shoulder surgery, a potentially detrimental influence on cerebral oxygenation is discussed. Therefore, the present study investigated changes in regional cerebral oxygen saturation (rSO2/StO2) during BCP comparing 2 different devices for near-infrared spectroscopy measurement. ⋯ BCP is associated with a decrease in rSO2/StO2 of 10% in anesthetized patients, which is reversible after repositioning. No changes occurred in supine position under general anesthesia as well as in awake subjects in BCP. This underlines the assumption that vasodilation by anesthetics in combination with BCP evoke a drop in rSO2/StO2. A strict hemodynamic management may be necessary to prevent desaturation events. Despite different technology used by the devices, the results of INVOS and FORE-SIGHT cerebral oximeters are comparable.