The British journal of dermatology
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Randomized Controlled Trial Multicenter Study Clinical Trial
A randomized, placebo-controlled, double-blind trial of ondansetron in renal itch.
Renal itch is a relatively common and distressing problem for patients with chronic renal failure. Ondansetron, a serotonin type 3 receptor antagonist was developed for relief of chemotherapy induced nausea. Recently, anecdotal reports describe relief of renal itch with ondansetron. ⋯ Our results show that ondansetron is no better than placebo in controlling renal itch.
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Bullous pemphigoid (BP) is an autoimmune blistering disease characterized by eosinophilia and high serum IgE levels. The accumulated evidence suggests that various cytokines are involved in the lesional skin of patients with BP. Recently, thymus and activation-regulated chemokine (TARC/CCL17), a CC chemokine, was identified as a selective chemoattractant for CC chemokine receptor 4 (CCR4)-expressing cells. ⋯ These findings strongly suggest that TARC may be one of the important chemokines that are involved in the pathogenesis of BP.