European journal of internal medicine
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IgG4-related disease (IgG4-RD) is an autoimmune disorder characterized by substantial infiltration of plasma cells with IgG4 in target organs. Lung manifestations predominantly present as inflammatory pseudotumor, interstitial pneumonitis, organizing pneumonia, and lymphomatoid granulomatosis. ⋯ The long-term prognosis of IgG4-RLD remains unknown. In this review, we summarized the current diagnostic algorithms and discussed potential biomarkers for future investigation.
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Eur. J. Intern. Med. · Aug 2019
ReviewNew oncologic emergencies: What is there to know about inmunotherapy and its potential side effects?
Over the last decade anticancer treatment has experienced encouraging changes. One of the latest developments is immunotherapy, which is increasingly becoming a mainstay for the treatment of these malignancies. Unlike conventional chemotherapy, immunotherapy enhances anti-tumor immune response by blocking inhibitory immune checkpoints, and allowing our own immune system to fight against the tumor cells, arising as a new and innovative mechanism of action. ⋯ Adverse effects of immunotherapy are most commonly observed in the skin, gastrointestinal tract, liver, lung and endocrine systems. Less common toxicities may include neurological, haematological, cardiac, ocular or rheumatologic involvement. As far as we know, cancer patients are frequently seen in the Emergency Department due to treatment related toxicities, thus there is an increasing necessity to learn about this particular side effect profile given that they entail a different and unique management than that of classic chemotherapy drugs.
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Eur. J. Intern. Med. · Aug 2019
Lung ultrasonography in pulmonary tuberculosis: A pilot study on diagnostic accuracy in a high-risk population.
The validity of lung ultrasound (LUS) in the diagnosis of interstitial or focal lung pathologies is well documented, we assessed its accuracy in the diagnosis of pulmonary tuberculosis (PTB). ⋯ Our data suggest a possible role of LUS in the diagnosis of PTB, a high burden pathological condition for which the delay in diagnosis still represents a critical point in the control of the disease.
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Eur. J. Intern. Med. · Aug 2019
Multicenter StudyExternal validation of the CACE-HF risk score for mortality in patients with heart failure.
To validate externally the CACE-HF clinical prediction rule, which predicts 1-year mortality in patients with heart failure (HF). ⋯ The results of the external validation of the CACE-HF risk score show that although the capacity for discrimination was slightly lower than in the derivation cohort, the calibration was excellent. This tool, therefore, can assist in decision-making in the management of these patients.
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Eur. J. Intern. Med. · Aug 2019
Multicenter StudyBody mass index as a driver of selection of biologic therapy in rheumatoid arthritis. Results from the US-CLARA study.
Body mass index (BMI) demonstrated to influence the clinical response to different drugs in rheumatoid arthritis (RA). The aim of this study was to investigate the role of BMI in the achievement of remission in active RA patients starting the treatment with abatacept. ⋯ BMI does not influence the abatacept response in RA patients with active disease. During abatacept treatment, the clinical response can be achieved despite a condition of overweight or obesity.