Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Oct 1996
Randomized Controlled Trial Comparative Study Clinical TrialEpidural vs. intravenous infusion of alfentanil in the management of postoperative pain following laparotomies.
This study was designed to compare the efficacy of epidural vs. intravenous administration of alfentanil for treatment of postoperative pain. ⋯ Compared to intravenous infusion of alfentanil epidural infusion resulting in the same plasma concentrations is not more effective in relieving postoperative pain. In view of this observation we were not able to demonstrate a spinal mechanism of alfentanil.
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Acta Anaesthesiol Scand · Oct 1996
Randomized Controlled Trial Clinical TrialCardiovascular effects of desflurane and isoflurane in patients with coronary artery disease.
Anaesthesia in patients with ischaemic heart disease may cause adverse haemodynamic reactions. This investigation compares the cardiovascular effects of equipotent concentrations of desflurane and isoflurane in 30 patients (ASA III) with coronary artery disease before surgical stimulation. ⋯ The results of this study demonstrate that in patients with coronary artery disease the haemodynamic effects of equipotent concentrations of desflurane and isoflurane are similar except for a significant increase in PAP and PCWP caused by desflurane. Therefore, desflurane should be administered with great caution if it is used as an alternative anaesthetic in patients with ischaemic heart disease.