Acta anaesthesiologica Scandinavica
-
Acta Anaesthesiol Scand · Sep 1996
Randomized Controlled Trial Clinical TrialThe combination of morphine with local anaesthetic in rhinoplasty--no evidence of a peripheral morphine effect.
The recognition of a peripheral opioid action has prompted a number of clinical reports demonstrating a prolonged analgesic effect of peripheral opiate. As most studies have used a model of intraarticular instillation of narcotic we examined direct morphine infiltration of the surgical site in a unique clinical model. ⋯ The results of this study indicate that the preoperative injection of intrawound morphine in combination with the local anesthetic both promotes bleeding and has an early pain-enhancing effect while providing no late analgesic benefit beyond that of IM morphine.
-
Acta Anaesthesiol Scand · Sep 1996
Randomized Controlled Trial Clinical TrialPreoperative ketorolac administration has no preemptive analgesic effect for minor orthopaedic surgery.
The utility of preoperative ketorolac administration to reduce the intensity and duration of postoperative pain was compared with placebo in a randomized double-blind design of 60 ASA 1-2 patients scheduled for minor orthopaedic surgery. No opioids nor local anaesthetic blocks were used during surgery. The patients received either 30 mg ketorolac IV before surgery followed by a placebo injection after surgery or the reverse. ⋯ No differences in pain intensity were observed between the two groups except for the initial 15-min postoperative assessments in the ketorolac group. The time to first rescue morphine administration and the total morphine consumption during the 6-h observation period were similar. It is concluded that the preoperative administration of ketorolac did not provide a significant preemptive analgesic benefit with regard to postoperative pain relief and opioid dose-sparing effect.
-
Acta Anaesthesiol Scand · Sep 1996
Randomized Controlled Trial Clinical TrialIs sufentanil a useful opioid for laryngomicroscopy?
Alfentanil is commonly used as opioid analgesic for short surgical procedures. Little is known about the usefulness of sufentanil for this purpose. We investigated the effects of alfentanil and sufentanil on haemodynamic characteristics, catecholamine levels, and adrenocorticotropic hormone (ACTH) and cortisol contents during elective laryngomicroscopy and short laryngeal surgery (LM). ⋯ Clinical recovery is achieved most rapidly with alfentanil in ultra short surgical procedures. However, if surgery is expected to be longer than about 12 min also sufentanil at a dose of 0.25 micrograms/kg seems to be useful for this kind of surgery.