Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Jul 1999
Randomized Controlled Trial Clinical TrialPollution with nitrous oxide using laryngeal mask or face mask.
As environmental pollution by nitrous oxide may influence the health of the personnel working in operating theatres, the incidence and magnitude of nitrous oxide (N2O) leakage, when using a face mask or a laryngeal mask airway (LMA) for controlled ventilation, were studied in 34 patients scheduled for elective cystoscopy. ⋯ Environmental pollution was less with the LMA than the face mask, but under the conditions of the study both modes of airway management were associated with levels of N2O peak concentrations in the breathing zone of anaesthetists that are deemed to be excessively high by the Danish National Institute for Occupational Safety.
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Acta Anaesthesiol Scand · Jul 1999
Case ReportsClinical experience using intrathecal (IT) bupivacaine infusion in three patients with complex regional pain syndrome type I (CRPS-I).
To date, there is no reliable method for treating the severe pain and for modifying the natural evolution of CRPS-I. Therefore, we explored the effect of long-term IT bupivacaine infusion (with or without buprenorphine) on this syndrome. ⋯ The IT pain treatment with bupivacaine (with or without buprenorphine) alleviated the "refractory" pain, but affected neither the associated symptoms and signs of the CRPS-I, nor its natural evolution. Thus, the IT treatment cannot be recommended in preference to other pain treatment regimens for CRPS-I.
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Acta Anaesthesiol Scand · Jul 1999
An alternative method to intubate with laryngeal mask and see-through-bougie.
Different ways of managing the difficult airway is an important issue for the anaesthetist. We have investigated a technique with a see-through-bougie and laryngeal mask for intubation. ⋯ We conclude that intubation using a see-through-bougie and a laryngeal mask is a valuable method in the difficult intubation situation, when a temporary airway can be achieved with laryngeal mask, since it permits continuous ventilation and visual control throughout the procedure.
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Acta Anaesthesiol Scand · Jul 1999
Investigation of fading responses induced by non-depolarising muscle relaxants in the evoked EMG of the gastrocnemius muscle of the cat.
During partial neuromuscular blockade indirect repetitive nerve stimulation causes fade in the response of the muscle. We studied the intensity of the fade induced by intravenous administration of three steroidal muscle relaxants, and investigated the mechanism of fade by comparing with results obtained during partial blockade with animal toxins and vesamicol. ⋯ Our results suggest that non-depolarising muscle relaxant-induced fade is caused by an inhibitory effect on acetylcholine release. Pancuronium seems to have a higher potency of presynaptic inhibition of acetylcholine release than both rocuronium and vecuronium.
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Acta Anaesthesiol Scand · Jul 1999
Pharmacology of G-1-64, a new nondepolarizing neuromuscular blocking agent with rapid onset and short duration of action.
Chances are slim that a clinically useful ultra-short-acting neuromuscular blocking agent of rapid onset will emerge from the benzylisoquinolinium or the aminosteroid series to which all currently popular relaxants belong. G-1-64 is a promising prototype of a new series of bis-quaternary ammonium salt of bistropinyl diester derivatives we have synthesized and studied in the laboratory. ⋯ With favorable neuromuscular blocking characteristics and modest side effects, G-1-64 and similar derivatives may have clinical potential.