Acta anaesthesiologica Scandinavica
-
Acta Anaesthesiol Scand · Jan 2002
Randomized Controlled Trial Comparative Study Clinical TrialCost-effectiveness of analgesia after Caesarean section. A comparison of intrathecal morphine and epidural PCA.
Patient-controlled analgesia (PCA) techniques and intrathecal morphine are the most widely used treatments for post-Caesarean section pain. However these methods have not been compared with respect to analgesic quality and cost differences. ⋯ It was concluded that epidural PCA induced better pain relief, caused less nausea/vomiting but was more expensive than intrathecal morphine.
-
Acta Anaesthesiol Scand · Jan 2002
Randomized Controlled Trial Comparative Study Clinical TrialEffect of amino acid solutions on intraoperative hypothermia and postoperative shivering. Comparison of two anesthetic regimens.
Intraoperative hypothermia is a major adverse effect of general anesthesia. The different anesthetics may influence thermoregulation differently. Proteins or amino acids have been postulated to stimulate heat production. The purpose of this study is to compare the effects of intraoperative administration of amino acid solutions on intraoperative hypothermia and postoperative shivering in two different anesthetic regimens. ⋯ The anesthetic method may influence the thermic effect of amino acids under general anesthesia. Propofol anesthesia has more thermogenic effect than isoflurane when combined with amino acid solutions.
-
Acta Anaesthesiol Scand · Jan 2002
Randomized Controlled Trial Clinical TrialIntravenous fluids warming by mattress is simple and efficient during pediatric surgery.
Temperature control is essential during pediatric surgery. The effectiveness of two methods of warming intravenous (i.v.) fluids to preserve normothermia was compared during abdominal surgery. ⋯ The increase in CT was more pronounced in patients where fluids were warmed under the warming mattress (Group M) than in those with fluids warmed by a coil warming device (Group T). The elevation in CT seen in Group M is associated with an increase in infusion fluid temperature at the line just before the i.v. cannula. Both methods of fluid warming (by placing the i.v. tubing under warming mattress and by using a fluid warming system) effectively preserved normothermia during abdominal surgery in children.
-
Acta Anaesthesiol Scand · Jan 2002
Intrathecal administration of liposomal neostigmine prolongs analgesia in mice.
There is substantial evidence that cholinomimetic drugs increase pain threshold. However, the profound side effects of these agents have limited their clinical use either as analgesics or as analgesic adjuncts. A delivery system that would assure a slow and sustained drug release may be of value in ameliorating the problem of untoward effects. ⋯ Liposomal neostigmine provides prolonged spinal antinociception, and permits the safe administration of a relatively large dose, because drug is gradually released from the liposomal depot. This technology holds promise for the development of a clinically useful neostigmine formulation to provide spinal analgesia.