Acta anaesthesiologica Scandinavica
-
Acta Anaesthesiol Scand · Feb 2002
Case ReportsAnalgesia for pelvic and perineal cancer pain by intrathecal steroid injection.
Corticosteroids are used systemically in patients with advanced cancer to alleviate pain. Intrathecal administration of steroids is rarely performed but analgesic effects of intrathecal steroids have been reported in animal studies. We administered betamethasone intrathecally in three cancer patients with uncontrollable pain. ⋯ Intrathecal injection of betamethasone may be a useful approach in some patients with intractable cancer pain.
-
Acta Anaesthesiol Scand · Feb 2002
Randomized Controlled Trial Clinical TrialPostoperative muscle paralysis after rocuronium: less residual block when acceleromyography is used.
Residual muscle paralysis after anesthesia is common after pancuronium, but less common following the intermediate-acting drugs vecuronium and atracurium. Therefore, many anesthetists do not monitor neuromuscular function when using an intermediate-acting agent. The purpose of this prospective, randomised and double-blind study was to establish the incidence and degree of postoperative residual block following the use of rocuronium in patients not monitored with a nerve stimulator, and to compare it with results obtained in patients monitored using acceleromyography (AMG). ⋯ Clinical evaluation of recovery of neuromuscular function does not exclude significant residual paralysis following the intermediate-acting muscle relaxant rocuronium, but the problem of residual block can be minimized by use of AMG.
-
Acta Anaesthesiol Scand · Feb 2002
Randomized Controlled Trial Comparative Study Clinical TrialParenteral ketoprofen for pain management after adenoidectomy: comparison of intravenous and intramuscular routes of administration.
Different parenteral routes of administration of NSAIDs such as ketoprofen have not been properly compared in children. This study was designed to compare the analgesic efficacy of intravenous and intramuscular ketoprofen for pain management in children after day-case adenoidectomy. ⋯ The efficacy of intravenous and intramuscular ketoprofen was similar, and they both differed from placebo.
-
Acta Anaesthesiol Scand · Feb 2002
Randomized Controlled Trial Clinical TrialAlbumin extravasation and tissue washout of hyaluronan after plasma volume expansion with crystalloid or hypooncotic colloid solutions.
Intravascular volume expansion is followed by loss of fluid from the circulation. The extravasation of albumin in this readjustment is insufficiently known. ⋯ Infusion of hypotonic colloidal solutions entails net loss of albumin from the vascular space. This is not the case after Ringer's acetate. Increased interstitial hydration from the latter fluid is followed by lymphatic wash out of hyaluronan.
-
Acta Anaesthesiol Scand · Feb 2002
Randomized Controlled Trial Clinical TrialEffect of metoclopramide on mivacurium-induced neuromuscular block.
In order to investigate the effect of metoclopramide on the duration of action of mivacurium, 45 patients were randomized into three groups. Group M10 (n = 15) and M20 (n = 15) received 10 and 20 mg of metoclopramide i.v., respectively, and group S (n = 15) received saline 2 min before induction of anesthesia with fentanyl, thiopental and mivacurium. Plasma cholinesterase activity (pCHE) was measured before induction of anesthesia and 2 min after injection of metoclopramide and saline. ⋯ Time to recovery of a twitch height of 90% was significantly prolonged in group M10 and M20 (44 +/- 15 and 57 +/- 10 min) as compared to group S, 32 +/- 9 min, P < 0.05). A slight but significant decrease in pCHE was observed in group M20. Because of the risk of prolonged duration of action of mivacurium, neuromuscular blockade should always be monitored whenever metoclopramide is given before injection of mivacurium.