Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Feb 2003
Randomized Controlled Trial Clinical TrialEffects of high-dose propofol on succinylcholine-induced fasciculations and myalgia.
The purpose of this prospective study was to determine the effects of high-dose propofol on the incidence of fasciculations and myalgia, and to evaluate changes in creatine kinase levels following the administration of succinylcholine in 90 women who underwent laparoscopy. ⋯ Administration of propofol 3.5 mg kg-1 is effective in reducing fasciculations and myalgia after succinylcholine.
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Acta Anaesthesiol Scand · Feb 2003
Randomized Controlled Trial Comparative Study Clinical TrialSevoflurane versus isoflurane--anaesthesia for lower abdominal surgery. Effects on perioperative glucose metabolism.
The aim of this study was to determine the impact of sevoflurane anaesthesia on metabolic and endocrine responses to lower abdominal surgery. ⋯ Sevoflurane, as well as isoflurane, does not prevent the metabolic endocrine responses to surgery.
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Acta Anaesthesiol Scand · Feb 2003
Anesthesiologists in prehospital care make a difference to certain groups of patients.
Knowledge of the population using prehospital emergency services is scarce except for selected subgroups. Interventions are often made without evaluation. The aim of this study was (1) to describe mortality, hospitalization and the diagnostic pattern among emergency ambulance users and (2) to evaluate the impact of one mobile emergency care unit (MECU) staffed by an anesthesiologist. ⋯ The diagnostic pattern among emergency ambulance users included all main groups of diseases. After the MECU fewer were brought to hospital. The overall mortality for all ambulance users was not influenced by the MECU. For the subgroups, especially AMI, mortality was lower after the introduction of the MECU.
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Acta Anaesthesiol Scand · Feb 2003
Effects of human cathelicidin antimicrobial peptide LL-37 on lipopolysaccharide-induced nitric oxide release from rat aorta in vitro.
Lipopolysaccharides (LPS), released by Gram-negative bacteria, cause vascular expression of inducible nitric oxide synthase (iNOS) leading to nitric oxide (NO) production and septic shock. Human cathelicidin antimicrobial peptide (LL-37) can bind and neutralize LPS. We wanted to study whether LL-37 affects LPS or interleukin-1beta (IL-1beta)-induced production, release and function of NO in intact rat aorta rings and cultured rat aorta smooth muscle cells. ⋯ IL-37 reduces NO production induced by LPS and IL-1beta. The reduction does not seem to result only from neutralization of LPS but also from a cytotoxic effect, possibly via induction of apoptosis.