Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Sep 2011
Randomized Controlled TrialSevere traumatic brain injury: consequences of early adverse events.
Several factors associated with an unfavourable outcome after severe traumatic brain injury (TBI) have been described: prolonged pre-hospital time, secondary referral to a level 1 trauma centre, the occurrence of secondary insults such as hypoxia, hypotension or low end-tidal carbon dioxide (ETCO(2)). To determine whether adverse events were linked to outcome, patients with severe TBI were studied before arrival at a level 1 trauma centre. ⋯ Early adverse events before arrival at a level 1 trauma centre were without significance for outcome after severe TBI in the trauma system studied.
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Acta Anaesthesiol Scand · Sep 2011
Randomized Controlled TrialEffect of N-acetylcysteine on cardiac injury and oxidative stress after abdominal aortic aneurysm repair: a randomized controlled trial.
Several studies have reported that the antioxidant properties of N-acetylcysteine (NAC) can provide cardiac protection through scavenging of free radicals. The present study was aimed to assess the efficacy of NAC for cardiac protection in patients undergoing elective abdominal aortic aneurysm (AAA) repair. ⋯ NAC infusion provided cardiac protection through scavenging of oxygen free radicals.
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Acta Anaesthesiol Scand · Sep 2011
Randomized Controlled TrialEffect of L-carnitine on oxidative stress and platelet activation after major surgery.
The surgical/anesthesia trauma is associated with an increased production of reactive oxygen species (ROS). This enhanced oxidative stress leads to cell damage resulting in various complications such as sepsis, myocardial injury and increased mortality. The aim of this study was to investigate the role of antioxidant treatment with l-carnitine in oxidative stress and platelet activation in patients undergoing major abdominal surgery. ⋯ Our findings suggest that l-carnitine could be helpful in modulating oxidative stress and platelet activation during major abdominal surgery-dependent oxidative damage.
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Acta Anaesthesiol Scand · Sep 2011
Randomized Controlled TrialIncreased lung clearance of isoflurane shortens emergence in obesity: a prospective randomized-controlled trial.
There is a concern that obesity may play a role in prolonging emergence from fat-soluble inhalational anaesthetics. We hypothesized that increased pulmonary clearance of isoflurane will shorten immediate recovery from anaesthesia and post-anaesthesia care unit (PACU) stay in obese patients. ⋯ Increasing alveolar ventilation enhances anaesthetic elimination and accelerates short-term recovery in obese patients.