Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Apr 2013
Effects of dexmedetomidine on inflammatory responses in patients undergoing laparoscopic cholecystectomy.
Dexmedetomidine has been shown to reduce pro-inflammatory cytokine levels in rats with sepsis and in severely ill patients. The aim of this study was to document the effects of dexmedetomidine on inflammatory responses during and after surgery. ⋯ Dexmedetomidine administration during surgery reduced intraoperative and post-operative secretion of cytokines, as well as post-operative leukocyte count and CRP level.
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Acta Anaesthesiol Scand · Apr 2013
Retraction Of PublicationRetraction. Preoperative oral granisetron prevents postoperative nausea and vomiting.
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Acta Anaesthesiol Scand · Apr 2013
Case ReportsAtypical upswing at initial part of phase III in capnograms due to technical cause.
We sporadically experienced three paediatric cases of atypical upswing at the initial part of phase III in the capnograms via side-stream capnometer immediately following endotracheal intubation and mechanical ventilation. No fault was found in the monitor or anaesthetic system including breathing circuits, carbon dioxide (CO2 ) sampling tube, water trap, and unidirectional valves. The upsurge of CO2 disappeared with increasing the respiratory rate; however, it reappeared with decreasing the respiratory rate and vice versa. We experimentally reproduced the phenomenon of overshooting CO2 measurement after the luer lock connection of the sample gas line at the water trap had been unscrewed a little bit.
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Acta Anaesthesiol Scand · Apr 2013
The effect of the molecular adsorbent recirculating system on moxifloxacin and meropenem plasma levels.
Adequate plasma antibiotic concentrations are necessary for effective elimination of invading microorganism; however, extracorporeal organ support systems are well known to alter plasma concentrations of antibiotics, requiring dose adjustments to achieve effective minimal inhibitory concentrations in the patient's blood. ⋯ Our data provide evidence that moxifloxacin and meropenem are effectively removed from the patient's blood by MARS, leading to low plasma levels. Dose adjustments of both antibiotic compounds may be required.