Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Sep 2015
Multicenter StudyRenal function and symptoms/adverse effects in opioid-treated patients with cancer.
Renal impairment and the risk of toxicity caused by accumulation of opioids and/or active metabolites is an under-investigated issue. This study aimed at analysing if symptoms/adverse effects in opioid-treated patients with cancer were associated with renal function. ⋯ Only severe constipation and loss of appetite were associated with low GFR in patients treated with morphine. Oxycodone and fentanyl, in relation to the symptoms studied, seem to be safe as used and titrated in routine cancer pain care.