Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Aug 2017
Randomized Controlled Trial Multicenter StudyFactors associated with early extubation after superior cavopulmonary connection: analysis from single ventricle reconstruction trial.
To evaluate the landscape of early extubation, and identify factors associated with early extubation (≤ 24 h) after superior cavopulmonary connection (stage 2 operation) among children with single ventricle anatomy. ⋯ Data from this large multicenter study demonstrate that approximately one-half of the patients undergoing operation for superior cavopulmonary connection are extubated within 24 h after heart operation. Furthermore, early extubation is associated with shorter hospital length of stay.
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Acta Anaesthesiol Scand · Aug 2017
Randomized Controlled Trial Multicenter StudyStress ulcer prophylaxis in the intensive care unit trial: detailed statistical analysis plan.
In this statistical analysis plan, we aim to provide details of the pre-defined statistical analyses of the Stress Ulcer Prophylaxis in the Intensive Care Unit (SUP-ICU) trial. The aim of the SUP-ICU trial is to assess benefits and harms of stress ulcer prophylaxis with a proton pump inhibitor in adult patients in the intensive care unit (ICU). ⋯ Stress ulcer prophylaxis is standard of care in ICUs worldwide, but has never been tested in large high-quality randomised placebo-controlled trials. The SUP-ICU trial will provide important high-quality data on the balance between the benefits and harms of stress ulcer prophylaxis in adult critically ill patients.