Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · May 2021
Bronchially instilled IgY-antibodies did not decrease pulmonary P. aeruginosa concentration in experimental porcine pneumonia.
P. aeruginosa possesses antibiotic resistance, making treatment difficult. Polyclonal anti-P. aeruginosa IgY-antibodies (Pa-IgY) have antibacterial effects, but have not been studied in large animal pneumonia. ⋯ The chosen dose of Pa-IgY did not decrease concentrations of P. aeruginosa in BAL over 27 hours. We conclude that it is unlikely that there is a large effect of this specific dose and route of administration of Pa-IgY in this type of model.
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Acta Anaesthesiol Scand · May 2021
Randomized Controlled TrialTime to ventilation and success rate of airway devices in microgravity: A randomized crossover manikin-trial using an underwater setting.
Medical support for space exploration missions must prepare for severe medical events in conditions of microgravity. A key component to managing these events is techniques of airway management. The aim of the present trial is to compare airway management devices in simulated microgravity. ⋯ In simulated microgravity conditions, use of the laryngeal tube or laryngeal mask provided the quickest time to initial ventilation, without deliberate tethering of the mannequin and rescuer to a fixed surface. Endotracheal intubation required significantly longer procedure times and, thus, was considered insufficient for clinical use in microgravity.