Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Jul 2022
ReviewConservative vs. liberal fluid therapy in septic shock - protocol for secondary Bayesian analyses of the CLASSIC trial.
Clinical equipoise exists regarding intravenous (IV) fluid volumes in sepsis. The Conservative vs. Liberal Approach to fluid therapy of Septic Shock in Intensive Care (CLASSIC) trial investigates the effect of restricted vs. standard IV fluid therapy in 1554 adult intensive care unit patients with septic shock. ⋯ The outlined analyses will supplement the primary analysis of the CLASSIC trial by describing probabilities of beneficial and harmful effects and evaluating heterogeneity of treatment effects in a framework that may be easier to interpret for researchers and clinicians.