Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Apr 2023
Randomized Controlled Trial Multicenter StudyGoal-directed fluid removal with furosemide versus placebo in intensive care patients with fluid overload: a randomised, blinded trial (GODIF trial - first version).
Salt and water accumulation leading to fluid overload is associated with increased mortality in intensive care unit (ICU) patients, but diuretics' effects on patient outcomes are uncertain. In this first version of the GODIF trial, we aimed to assess the effects of goal-directed fluid removal with furosemide versus placebo in adult ICU patients with fluid overload. ⋯ The use of cumulative fluid balance as the only estimate of fluid status appeared too difficult to use in clinical practice. We were unable to provide precise estimates for any outcomes as only 4.1% of the planned sample size was randomised.
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Acta Anaesthesiol Scand · Apr 2023
Multicenter StudyIntra-operative blood transfusion in elderly patients on antithrombotic therapy.
Many elderly patients are receiving antithrombotics, which may increase intra-operative blood loss. We aimed to assess whether chronic antithrombotic therapy was associated with intra-operative transfusion of packed red blood cells in patients at least 80 years of age undergoing elective procedures. ⋯ A total of 7174 patients were included of whom 4073 (56.8%) were on antithrombotic therapy. Among patients on antithrombotic therapy 191 (4.7%) received intra-operative blood transfusion compared with 98 (3.2%) of patients not on chronic antithrombotic therapy (crude odds ratio: 1.51, 95% CI 1.18-1.94). Following multiple logistic regression analysis, the adjusted odds ratio was 0.98; 0.73-1.32. We found that chronic antithrombotic therapy was associated with intra-operative transfusion of packed red blood cells in elderly patients undergoing elective procedures in an unadjusted analysis, but not in a multivariate adjusted model.
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Acta Anaesthesiol Scand · Apr 2023
Multicenter Study Observational StudyQuantification of Exhaled Propofol Is Not Feasible During Single-Lung Ventilation Using Double-Lumen Tubes: A Multicenter Prospective Observational Trial.
Volatile propofol can be measured in exhaled air and correlates to plasma concentrations with a time delay. However, the effect of single-lung ventilation on exhaled propofol is unclear. Therefore, our goal was to evaluate exhaled propofol concentrations during single-lung compared to double-lung ventilation using double-lumen tubes. ⋯ DRKS-ID DRKS00014788 (www.drks.de).