Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Aug 2023
Randomized Controlled TrialMild induced hypothermia and coagulation and platelet function in patients with septic shock: Secondary outcome of a randomized trial.
Coagulation abnormalities and microthrombi contribute to septic shock, but the impact of body temperature regulation on coagulation in patients with sepsis is unknown. We tested the hypothesis that mild induced hypothermia reduces coagulation and platelet aggregation in patients with septic shock. Secondary analysis of randomized controlled trial. ⋯ Platelet aggregation was slightly impaired. The effect of mild induced hypothermia on viscoelastography and platelet aggregation was however not in a range that would have clinical implications. We did observe a substantial reduction in fibrinolysis.