Acta anaesthesiologica Scandinavica
-
Acta Anaesthesiol Scand · Jul 2024
Multicenter StudyEmpirical carbapenems or piperacillin/tazobactam for infections in intensive care: An international retrospective cohort study.
Critically ill patients in intensive care units (ICU) are frequently administered broad-spectrum antibiotics (e.g., carbapenems or piperacillin/tazobactam) for suspected or confirmed infections. This retrospective cohort study aimed to describe the use of carbapenems and piperacillin/tazobactam in two international, prospectively collected datasets. ⋯ In this post hoc analysis of ICU patients with infections, we found widespread initial use of carbapenems and piperacillin/tazobactam in international ICUs, with the latter being more frequently used. Randomized clinical trials are needed to assess if the observed variations in outcomes may be drug-related effects or due to confounders.
-
Acta Anaesthesiol Scand · Jul 2024
Multicenter StudyAssociation of perioperative transfusion of fresh frozen plasma and outcomes after cardiac surgery.
Fresh frozen plasma (FFP) transfusion is used to manage coagulopathy and bleeding in cardiac surgery patients despite uncertainty about its safety and effectiveness. ⋯ In a multicentre, propensity score matched analysis, perioperative FFP transfusion was associated with increased 30-day mortality and had variable associations with secondary clinical outcomes.