Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Apr 2019
Review Meta AnalysisDexmedetomidine for the prevention of delirium in critically ill patients - A protocol for a systematic review.
Delirium is a common complication in critically ill patients and carries an increased risk of mortality and morbidity. Dexmedetomidine can potentially prevent delirium by diminishing predisposing factors. The evidence regarding the use of dexmedetomidine in preventing delirium is conflicting. This protocol aims to identify the beneficial and harmful effects of dexmedetomidine in the prevention of delirium. ⋯ This systematic review can potentially aid clinicians in decision-making and benefit the many critically ill patients at risk of delirium.
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Acta Anaesthesiol Scand · Apr 2019
Review Meta AnalysisDopamine in critically ill patients with cardiac dysfunction: A systematic review with meta-analysis and trial sequential analysis.
Dopamine has been used in patients with cardiac dysfunction for more than five decades. Yet, no systematic review has assessed the effects of dopamine in critically ill patients with cardiac dysfunction. ⋯ Evidence for dopamine in critically ill patients with cardiac dysfunction is sparse, of low quality, and inconclusive. The use of dopamine for cardiac dysfunction can neither be recommended nor refuted.
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Acta Anaesthesiol Scand · Mar 2019
Review Meta AnalysisAerosolized corticosteroids to prevent postoperative sore throat in adults: A systematic review and meta-analysis.
Postoperative sore throat negatively affects patient recovery and satisfaction levels. We conducted a systematic review and meta-analysis to assess the efficacy and safety of aerosolized corticosteroids in the prevention of postoperative sore throat in adults undergoing tracheal intubation for surgery. ⋯ Aerosolized corticosteroids may be superior to non-analgesic methods in preventing postoperative sore throat, but the evidence for efficacy and safety is still limited and not definitive.
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Acta Anaesthesiol Scand · Feb 2019
Review Meta AnalysisThe effects of general anaesthesia on oxygen consumption: A meta-analysis guiding future studies on perioperative oxygen transport.
Increased oxygen extraction, the ratio of consumption to delivery, has been associated with poor outcome after surgery. Oxygen consumption (VO2) can change in several ways in the perioperative period, but is seldom monitored directly in routine care. This study investigates the effects of general anaesthesia on VO2. ⋯ General anaesthesia probably reduces oxygen consumption but the effect estimate is uncertain. Given the limited generalizability and low quality of the available evidence, new studies in modern perioperative settings and in today's older high-risk surgical patient populations are needed.
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Acta Anaesthesiol Scand · Nov 2018
Review Meta AnalysisPerioperative goal-directed therapy: A systematic review without meta-analysis.
Perioperative goal-directed therapy aims to optimise haemodynamics by titrating fluids, vasopressors and/or inotropes to predefined haemodynamic targets. Perioperative goal-directed therapy is a complex intervention composed of several independent component interventions. Trials on perioperative goal-directed therapy show conflicting results. We aimed to conduct a systematic review and meta-analysis to investigate the benefits and harms of perioperative goal-directed therapy. ⋯ Clinical heterogeneity in patients, interventions and outcomes in perioperative goal-directed therapy trials is too large to perform meta-analysis on all trials. Future trials and meta-analyses highly depend on universally agreed definitions on aspects beyond type of surgery of the complex intervention and its evaluation.