Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Apr 2019
Review Meta AnalysisLactate versus acetate buffered crystalloid solutions: Protocol for a scoping review.
Intravenous (IV) fluid therapy has become a ubiquitous intervention in everyday clinical practice. Several types of fluid are available including isotonic crystalloid fluids. Among crystalloid fluids, buffered solutions (derivatives of the original Hartmann's and Ringer's solutions) are increasingly recommended as first-line resuscitation fluids. However, the choice between different buffered solutions appears to be difficult with limited data to support the use of lactate vs. acetate buffered solutions. Accordingly, we aim at systematically describing the body of evidence on the use of the different types of buffered crystalloid solutions in hospitalised patients. ⋯ This outlined scoping review will provide a summary of the current body of evidence on the use, effects and side-effects of buffered crystalloid solutions. This will provide an important update of the current evidence on the use, of "buffered" crystalloid solutions including evidence of potential benefits and harms.
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Acta Anaesthesiol Scand · Apr 2019
Review Meta AnalysisDexmedetomidine for the management of delirium in critically ill patients-A protocol for a systematic review.
Delirium is a common complication in critically ill patients and carries an increased risk of mortality and morbidity. Dexmedetomidine can potentially treat delirium by diminishing predisposing factors. The evidence regarding the use of dexmedetomidine in the management of delirium is conflicting. This protocol aims to identify the beneficial and harmful effects of dexmedetomidine in the management of delirium. ⋯ This systematic review can potentially aid clinicians in decision making and benefit the many critically ill patients developing delirium.
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Acta Anaesthesiol Scand · Apr 2019
Review Meta AnalysisDexmedetomidine for the prevention of delirium in critically ill patients - A protocol for a systematic review.
Delirium is a common complication in critically ill patients and carries an increased risk of mortality and morbidity. Dexmedetomidine can potentially prevent delirium by diminishing predisposing factors. The evidence regarding the use of dexmedetomidine in preventing delirium is conflicting. This protocol aims to identify the beneficial and harmful effects of dexmedetomidine in the prevention of delirium. ⋯ This systematic review can potentially aid clinicians in decision-making and benefit the many critically ill patients at risk of delirium.
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Acta Anaesthesiol Scand · Apr 2019
Observational StudyLong-term mortality and cause of death for patients treated in Intensive Care Units due to poisoning.
Poisoned patients treated in the Intensive Care Unit are common, representing up to 6% of all ICU admissions. The in-hospital mortality is generally low but little is known about the long-term mortality in these patients. The aim of this study was to describe long-term mortality and cause of death in patients treated in the ICU for poisoning. ⋯ Admission to ICU with poisoning, and particularly self-poisoning, may be associated with long-term mortaliity. In this study of 6730 patients admitted to a Swedish ICU for poisoning, the in-hospital mortality was low for that admission, but there is an increased risk of later mortality in young patients one and two years after hospital discharge.
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Acta Anaesthesiol Scand · Apr 2019
Lower short-term mortality in ICU patients on chronic dialysis than in those requiring acute dialysis.
In ICU patients, we aimed to describe the outcomes of those with end-stage renal disease (ESRD) as compared to those requiring acute renal replacement therapy (RRT). ⋯ The crude mortality for patients with pre-existing ESRD was high. Short-term mortality was within range of those not receiving RRT when adjusted for confounders. The severity of acute illness and the burden of comorbidities may be more important than the lack of kidney function per se for the short-term prognosis of RRT patients in the ICU.