Archives of orthopaedic and trauma surgery
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Arch Orthop Trauma Surg · Jul 2001
Effect of chemotherapeutic agents on distraction osteogenesis. An experimental investigation in rabbits.
Limb-salvage operations such as vascularised or non-vascularised osseous grafts and allograft and callus distraction methods have replaced amputations because of the increase in the life expectancy of patients with malignant tumours. In this study we aimed to evaluate the effects of chemotherapeutic agents on distraction osteogenesis. For this purpose, 23 rabbits randomly divided into two groups were included in the study. ⋯ No difference between the two groups was observed in radiological, scintigraphical and histopathological studies carried out before the distraction period and following the end of the distraction period. In this study, it was shown that the use of antineoplastic drugs has no significant negative effect on distraction osteogenesis applied for reconstruction in rabbits. We think that it can be an alternative treatment method in humans as well.
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Arch Orthop Trauma Surg · Jul 2001
The contribution of vitamin C to healing of experimental fractures.
The benefits of various minerals and vitamins on fracture healing have been demonstrated in animal models. Vitamin C is an essential substance in fracture healing but has not been studied previously on an experimental basis. Sixteen rats were grouped randomly into control and vitamin C-supplemented groups. ⋯ One group received single high dose of vitamin C intramuscularly. On the 5th, 10th, 15th, and 20th days, two rats from each group were killed and the tibias examined under light microscopy. It was seen that the vitamin C-supplemented group went through the stages of fracture healing faster compared with the control group.
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Arch Orthop Trauma Surg · Jul 2001
Immunolocalization of the angiogenetic factor pleiotrophin (PTN) in the growth plate of mice.
The aim of this study was to find out whether and where the angiogenic agent pleiotrophin (PTN) occurs within the growth plate. We investigated paraffin-embedded tissue sections of ten male mice with an antibody directed against the recombinant PTN. ⋯ The resting zone and the proliferation zone were PTN negative. The results of our study suggest that the known angiogenetic peptide PTN plays a role in the process of angiogenesis in the growth plate.