Journal of nephrology
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Journal of nephrology · Mar 2010
Randomized Controlled Trial Comparative StudySodium bicarbonate in preventing contrast nephropathy in patients at risk for volume overload: a randomized controlled trial.
Sodium bicarbonate has been recently proposed as a prophylactic measure for the prevention of contrast-induced nephropathy (CIN). We aimed to compare the efficacy of the combination of sodium bicarbonate with half saline, and half saline alone in preventing CIN in patients having uncontrolled hypertension, compensated severe heart failure or a history of pulmonary edema. ⋯ The combination therapy of sodium bicarbonate plus half saline does not offer additional benefits over hydration with half saline alone in the prevention of CIN.