Journal of nephrology
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Journal of nephrology · Nov 2013
Amelioration of rhabdomyolysis-induced renal mitochondrial injury and apoptosis through suppression of Drp-1 translocation.
Mitochondrial dysfunction plays an important role in acute kidney injury (AKI). Mitochondrial fission regulated by dynamin-related protein 1 (Drp-1) impairs the function of the mitochondria and the survival of cells. This study was conducted to explore the effects of suppression of Drp-1 accumulation in the mitochondria, on mitochondrial function and renal tubular cell apoptosis in rhabdomyolysis (RM)-induced AKI. ⋯ To conclude, in RM-induced AKI, suppression of Drp-1 accumulation in mitochondria favors the maintenance of mitochondrial function and reduces the apoptosis of tubular cells. Regulation of the mitochondrial fusion-fission balance may offer a novel strategy for the prevention and treatment of RM-induced AKI.
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Journal of nephrology · Jul 2013
Microalbuminuria can predict the development of acute kidney injury in critically ill septic patients.
Microalbuminuria (MA) has long been associated with development of chronic kidney diseases in diabetic or hypertensive patients. However, its value in predicting acute kidney injury (AKI) in an intensive care unit (ICU) setting has never been reported. This study aimed to investigate the link between MA and AKI. ⋯ ACR obtained on entry to ICU was highly predictive of AKI, and was also associated with mortality rate and ICU length of stay.
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Journal of nephrology · Mar 2013
Comparative StudyStent-grafts versus angioplasty and/or bare metal stents for failing arteriovenous grafts: a cross-over longitudinal study.
A well-established method to preserve failing synthetic arteriovenous grafts (AVGs) dialysis accesses is percutaneous transluminal angioplasty (PTA). Nevertheless, the one-year primary patency rate following PTA is approximately 25%. This study was designed to compare the angiographic and clinical outcomes following stent-graft insertion versus angioplasty and/or bare metal stenting (BMS) of recurrently failing AVGs, because of anastomotic and/or venous outflow stenoses. ⋯ Stent-graft placement significantly improves primary patency of anastomotic and venous outflow stenoses in recurrently failing prosthetic arteriovenous grafts.
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Journal of nephrology · Mar 2013
Quantification of experimental acute kidney injury by computer-assisted imaging of lectin phytohemagglutinin E.
Acute kidney injury (AKI) in sepsis accompanied by functional impairment regularly lacks histologic pathology to a similar extent. Moderately reproducible - semi-quantitative - scoring systems still remain the method of choice to quantify the extent of experimental AKI. Our aim was to establish a rather simple, fast, and reproducible staining protocol to quantify loss of brush border (BB) in septic AKI. ⋯ Our results demonstrate that PHA-E lectin staining followed by planimetric quantification is a reliable tool to analyze loss of BB during experimental AKI.
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Journal of nephrology · Jan 2013
Comparative Study Controlled Clinical TrialVitamin D2 versus vitamin D3 supplementation in hemodialysis patients: a comparative pilot study.
In patients with chronic kidney disease, vitamin D insufficiency is highly prevalent. It can be corrected by supplementation with either vitamin D(2) or vitamin D3. Recent studies in patients without impaired kidney function suggest that vitamin D(3) is more efficient than vitamin D(2) in correcting vitamin D insufficiency. However, no direct comparison has been made in hemodialysis (HD) patients. ⋯ Vitamin D(3) is more effective than vitamin D(2) in providing adequate 25(OH)D serum levels in HD patients.