Journal of nephrology
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Journal of nephrology · Dec 2019
Randomized Controlled Trial Multicenter StudyTreatment of metabolic acidosis with sodium bicarbonate delays progression of chronic kidney disease: the UBI Study.
Metabolic acidosis is associated with accelerated progression of chronic kidney disease (CKD). Whether treatment of metabolic acidosis with sodium bicarbonate improves kidney and patient survival in CKD is unclear. ⋯ In persons with CKD 3-5 without advanced stages of chronic heart failure, treatment of metabolic acidosis with sodium bicarbonate is safe and improves kidney and patient survival.
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Journal of nephrology · Apr 2015
Randomized Controlled Trial Multicenter StudyAcute kidney injury after cardiac surgery: is minocycline protective?
Acute kidney injury (AKI) after cardiac bypass surgery (CABG) is common and carries a significant association with morbidity and mortality. Since minocycline therapy attenuates kidney injury in animal models of AKI, we tested its effects in patients undergoing CABG. ⋯ Minocycline did not protect against AKI post-CABG.
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Journal of nephrology · Feb 2015
Randomized Controlled TrialDiuretic response to colloid and crystalloid fluid loading in critically ill patients.
In the critically ill patient, fluid loading is commonly done to stabilise hemodynamics and increase diuresis, whereas the absence of diuresis may predispose to harmful overloading. The goal of the current study was to evaluate the diuretic response and determinants thereof upon crystalloid and colloid fluid loading. ⋯ In critically ill patients with clinical hypovolemia, diuresis increases more during saline than colloid fluid loading, only partly dependent of a fall in plasma COP.
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Journal of nephrology · Oct 2014
Randomized Controlled Trial Multicenter Study Comparative StudyThe extent of informed decision-making about starting dialysis: does patients' age matter?
A growing number of elderly patients with end-stage renal disease start dialysis. We examined elderly (≥65 years) patients' views about their decision-making experience after starting dialysis in comparison with patients aged 50-64 years, and patients ≤49 years. ⋯ Informed decision-making is significantly poorer in patients aged 65 years or older than in younger patients. Clinicians should communicate clearly about the benefits and burdens of dialysis to older adults and provide an opportunity for them to understand the significant trade-offs that dialysis may require.
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Journal of nephrology · Jan 2013
Randomized Controlled TrialIgA nephropathy with severe chronic renal failure: a randomized controlled trial of corticosteroids and azathioprine.
Therapeutic nihilism is common in IgA nephropathy (IgAN) and renal insufficiency. ⋯ Six-year renal survival was similar in the 2 groups. At Cox analysis the addition of azathioprine may be slightly more effective than corticosteroids alone in patients with chronic renal insufficiency, although with an increase of side effects.