Journal of nephrology
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Journal of nephrology · Dec 2019
Randomized Controlled Trial Multicenter StudyTreatment of metabolic acidosis with sodium bicarbonate delays progression of chronic kidney disease: the UBI Study.
Metabolic acidosis is associated with accelerated progression of chronic kidney disease (CKD). Whether treatment of metabolic acidosis with sodium bicarbonate improves kidney and patient survival in CKD is unclear. ⋯ In persons with CKD 3-5 without advanced stages of chronic heart failure, treatment of metabolic acidosis with sodium bicarbonate is safe and improves kidney and patient survival.
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Journal of nephrology · Apr 2019
Multicenter Study Comparative Study Observational StudyLeft Atrial Remodeling Assessed by Cardiac MRI after Conversion from Conventional Hemodialysis to In-Centre Nocturnal Hemodialysis.
Left atrial (LA) volume is a well-established cardiovascular prognosticator in patients with end-stage renal disease. Although dialysis intensification is associated with left ventricular mass regression, there are limited data regarding LA remodeling. Using cardiac magnetic resonance imaging (CMR), we examined changes in LA size and function relative to ventricular remodeling and cardiac biomarkers after dialysis intensification. ⋯ There was no significant change in LA size or systolic function after conversion to INHD. The significant correlations between LA and ventricular remodeling and cardiac biomarkers suggest common underlying pathophysiologic mechanisms.
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Journal of nephrology · Aug 2017
Multicenter StudyEffect of oral anticoagulant therapy on mortality in end-stage renal disease patients with atrial fibrillation: a prospective study.
The aim of this study was to evaluate, in a cohort of haemodialysis patients with atrial fibrillation (AF), the relationship between oral anticoagulant therapy (OAT) and mortality, thromboembolic events and haemorrhage. ⋯ In haemodialysis patients with AF, continuously taking warfarin is associated with a reduction of the risk of total and cardiovascular mortality.
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Journal of nephrology · Aug 2015
Multicenter StudyClinical determinants of reduced physical activity in hemodialysis and peritoneal dialysis patients.
The phenotype associated to reduced physical activity (PA) in dialysis patients is poorly documented. We here evaluate weekly PA in two independent cohorts. ⋯ There is a high prevalence of sedentary behavior in dialysis patients. Better physical activity was consistently associated with younger age, lower presence of comorbidities and better nutritional status. Pedometers represent a simple and inexpensive tool to objectively evaluate physical activity in this patient population.
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Journal of nephrology · Apr 2015
Randomized Controlled Trial Multicenter StudyAcute kidney injury after cardiac surgery: is minocycline protective?
Acute kidney injury (AKI) after cardiac bypass surgery (CABG) is common and carries a significant association with morbidity and mortality. Since minocycline therapy attenuates kidney injury in animal models of AKI, we tested its effects in patients undergoing CABG. ⋯ Minocycline did not protect against AKI post-CABG.