Journal of psychiatry & neuroscience : JPN
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J Psychiatry Neurosci · Jan 1998
Randomized Controlled Trial Comparative Study Clinical TrialSafety of ipsapirone treatment compared with lorazepam: discontinuation effects.
To determine discontinuation effects of ipsapirone, a novel azapirone and partial 5-HTIA agonist that has anxiolytic effects clinically and has not caused dependence or withdrawal symptoms in animals, and to compare these effects with those of the benzodiazepine lorazepam, owing to concern about dependence or withdrawal symptoms following use of these drugs. ⋯ Withdrawal symptoms were detected after discontinuation of therapeutic doses of lorazepam. Significantly fewer symptoms were observed after withdrawal from anxiolytic doses of ipsapirone.