Journal of psychiatry & neuroscience : JPN
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J Psychiatry Neurosci · Nov 1999
Case ReportsRefractory symptomatic schizophrenia resulting from frontal lobe lesion: response to clozapine.
A 34-year-old man with a 10-year history of persistent auditory hallucinations and passivity delusions had failed to respond to a variety of conventional antipsychotic medications. He had a history of head trauma 8 years before the onset of psychiatric symptoms. ⋯ Treatment with clozapine for more than 2 years resulted in a marked improvement in his psychotic symptoms. The localization of the brain lesion may be related to the etiology of his symptoms and to the clinical response to clozapine.
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J Psychiatry Neurosci · Nov 1999
Editorial CommentOptimism in the treatment of Alzheimer's disease.
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J Psychiatry Neurosci · Nov 1998
Case ReportsA case of risperidone overdose in early schizophrenia: a review of potential complications.
Deliberate drug overdose is a frequent occurrence in patients with schizophrenia. Typical antipsychotic medications can be lethal at doses 5 times the recommended therapeutic range. Clozapine, an atypical antipsychotic, can be toxic at doses 4 times a moderate dose. ⋯ To date, only 1 death attributable to risperidone overdose has been reported. The case presented here documents adverse cardiac effects in a 28-year-old man who intentionally ingested 24 mg of risperidone--4 times the recommended dose. A potential drug interaction with fluvoxamine and the role of active metabolites are discussed.
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J Psychiatry Neurosci · Jan 1998
Randomized Controlled Trial Comparative Study Clinical TrialSafety of ipsapirone treatment compared with lorazepam: discontinuation effects.
To determine discontinuation effects of ipsapirone, a novel azapirone and partial 5-HTIA agonist that has anxiolytic effects clinically and has not caused dependence or withdrawal symptoms in animals, and to compare these effects with those of the benzodiazepine lorazepam, owing to concern about dependence or withdrawal symptoms following use of these drugs. ⋯ Withdrawal symptoms were detected after discontinuation of therapeutic doses of lorazepam. Significantly fewer symptoms were observed after withdrawal from anxiolytic doses of ipsapirone.