International journal of obstetric anesthesia
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Int J Obstet Anesth · Apr 1998
Severe urticaria and pregnancy: use of the Internet to aid management.
A case of severe urticaria complicating pregnancy is described. Advice was sought and received from experts in the condition, using the Internet to exchange information. Epsilon-aminocaproic acid (EACA) was used with no apparent adverse effects. This case report highlights some of the problems of management of thi rare condition in pregnancy and obstetric anaesthesia, and the potential benefit of the Internet and its user groups.
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Int J Obstet Anesth · Apr 1998
Complete recovery after near-fatal venous air embolism during cesarean section.
During replacement to the abdomen of the exteriorized uterus at cesarean section under epidural block, a previously healthy woman developed cardiorespiratory arrest. Tracheal intubation revealed low end-tidal carbon dioxide concentration suggesting embolization. Resuscitative efforts were successful. Uterine exteriorization - as well as the Trendelenburg position - significantly increase the risk of air embolization so that routine use of appropriate monitors is indicated to facilitate early diagnosis.
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Int J Obstet Anesth · Apr 1998
Randomized Controlled Trial Clinical TrialMaternal, fetal and placental distribution of lidocaine-epinephrine and bupivacaine after epidural administration for cesarean section.
Bupivacaine and lidocaine are both lipophilic drugs, bupivacaine being more lipophilic and protein-bound. Our earlier studies, using human placenta perfused in vitro, showed that increased placental binding of bupivacaine restricts fetal transfer compared to the higher fetal transfer of lidocaine. However, placental tissue concentrations of local anesthetics have not been determined in the clinical context. ⋯ Values for area under the concentration-time curves per unit of dose were similar. In conclusion, maternal plasma concentrations, fetal/maternal concentration ratios and placental tissue binding of lidocaine resembled those of bupivacaine after epidural administration. These findings are probably explainable by the effect of maternal hypotension on the distribution of lidocaine.