Paediatric anaesthesia
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Paediatric anaesthesia · Jul 2003
Randomized Controlled Trial Clinical TrialDolasetron for the prevention of postoperative vomiting in children undergoing strabismus surgery.
Children undergoing strabismus surgery have a high incidence of postoperative vomiting (POV). The purpose of this study was to assess the efficacy and safety of dolasetron for the prevention of emesis comparing a single 0.35 mg.kg-1 or 12.5 mg dose with placebo. ⋯ There was no statistical difference between the 0.35 mg.kg-1 dose and the fixed 12.5 mg dose of dolasetron with both reducing the incidence of POV.
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Paediatric anaesthesia · Jul 2003
Randomized Controlled Trial Clinical TrialDose response study of caudal neostigmine for postoperative analgesia in paediatric patients undergoing genitourinary surgery.
Neostigmine given through the neuraxial route has been found to have analgesic properties. In this clinical trial, we evaluated for the first time the efficacy of a varying dose of caudal neostigmine for postoperative analgesia in children undergoing genitourinary surgery. ⋯ Caudal neostigmine in the dose range of 20-50 microgram.kg-1 provides dose dependent analgesia. However, dose exceeding 30 microgram.kg-1 is associated with a higher incidence of nausea and vomiting.