American journal of ophthalmology
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Randomized Controlled Trial Comparative Study
Intravitreal injection anesthesia--comparison of different topical agents: a prospective randomized controlled trial.
To compare the anesthetic effectiveness of 3 topical agents used for intravitreal injections. ⋯ There was no clinical difference in patient pain experience between the 3 anesthetic options tested. The addition of a 4% lidocaine pledget offered no clinical advantage in pain relief compared to 0.5% tetracaine or 4% cocaine (+ epinephrine 1/100,000) drops alone.
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Randomized Controlled Trial
Surveillance of the eye and vision in clinical trials of CP-675,206 for metastatic melanoma.
To determine the ocular safety of CP-675,206 (Pfizer, New York, New York, USA), a fully human anti-cytotoxic T lymphocyte-associated antigen 4 monoclonal antibody in clinical trials of immunotherapy of metastatic melanoma. ⋯ In this study, CP-675,206 immunotherapy for metastatic melanoma did not adversely affect the eye or vision.
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Randomized Controlled Trial Comparative Study
The effects of sevoflurane and ketamine on intraocular pressure in children during examination under anesthesia.
We studied the effects on intraocular pressure (IOP) of anesthesia administered during examination under anesthesia (EUA) in children. ⋯ IOP measured after ketamine sedation is more likely to represent the awake IOP than that after sevoflurane anesthesia. Changes in SBP, DBP, and HR caused by sevoflurane suggest that hemodynamic alterations may underlie its effects on IOP.
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Randomized Controlled Trial Comparative Study
"Instant vision" compared with postoperative patching: clinical evaluation and patient satisfaction after bilateral cataract surgery.
To compare two methods of postoperative dressing regimen: patching vs "instant vision" without patch. ⋯ The clinical examinations showed that both methods were equally safe for postoperative therapy. However, further efforts have to be made to increase the patients' comfort with "instant vision" in the first hours after cataract surgery.
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Randomized Controlled Trial Comparative Study
Topical gel vs subconjunctival lidocaine for intravitreous injection: a randomized clinical trial.
To determine if topical gel is superior to subconjunctival injection of lidocaine in relieving pain of intravitreous injection of corticosteroid. ⋯ The effective relief of pain with lidocaine for intravitreous injection is independent of its mode of application (gel vs subconjunctival injection).