American journal of ophthalmology
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Randomized Controlled Trial Clinical Trial
Lidocaine tape (Penles) reduces the pain of botulinum toxin injection for Meige syndrome.
To evaluate the efficacy of lidocaine tape in reducing pain during botulinum toxin injection. ⋯ Lidocaine tape is a simple and convenient method of reducing pain during botulinum toxin injection. This method is recommended for patients reluctant to receive this treatment because of pain during injection.
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Randomized Controlled Trial Comparative Study Clinical Trial
A randomized, placebo-controlled clinical trial of docosahexaenoic acid supplementation for X-linked retinitis pigmentosa.
Low docosahexaenoic acid (DHA) in X-linked retinitis pigmentosa (XLRP) may influence retinal function. The goals of this study were to elevate blood DHA levels and determine the effect on the rate of disease progression. ⋯ Although DHA-supplemented patients had significantly elevated mean RBC-DHA levels, the rate of cone ERG functional loss was not significantly different between groups. Supplemental analyses provided evidence for a DHA benefit and a direction for subsequent investigations.
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Randomized Controlled Trial Multicenter Study Clinical Trial
Outcomes of surgery for retinal detachment associated with proliferative vitreoretinopathy using perfluoro-n-octane: a multicenter study.
To report visual acuity and anatomical outcomes, as well as complications, of management of complex retinal detachment with proliferative vitreoretinopathy using pars plana vitrectomy and intraoperative perfluoro-n-octane (PFO), and to investigate clinical features associated with anatomical and visual acuity outcomes. ⋯ In the management of complex retinal detachment associated with proliferative vitreoretinopathy, pars plana vitrectomy and use of intraoperative PFO was associated with retinal reattachment and preserved visual acuity in most eyes.
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Randomized Controlled Trial Comparative Study Clinical Trial
Myopic astigmatism and presbyopia trial.
No prospective double-masked study has evaluated whether low astigmatism benefits or harms patients with presbyopia, whose intermediate and near vision might theoretically benefit from enhanced depth of focus provided by astigmatism. The purpose of the first Myopic Astigmatism and Presbyopia (MAP I) study was to determine whether low myopic astigmatism enhances or harms the visual acuity, stereopsis, or quality of life in patients with presbyopia. ⋯ This study has demonstrated that intermediate distance acuity and refractive quality of life are slightly better with spherical low myopic refractive error vs either astigmatic arm. Near and far distance acuity were unaffected by low myopic astigmatism compared with spherical low myopia. Near stereopsis was best in the ATR arms, but this did not produce better near visual acuity or RSVP quality of life.
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Randomized Controlled Trial Comparative Study Clinical Trial
A controlled trial of povidone-iodine to treat infectious conjunctivitis in children.
To report the efficacy of povidone-iodine as a treatment for conjunctivitis in pediatric patients. ⋯ Povidone-iodine 1.25% ophthalmic solution was as effective as neomycin-polymyxin B-gramicidin for treating bacterial conjunctivitis, somewhat more effective against chlamydia, and as ineffective against viral conjunctivitis. Povidone-iodine ophthalmic solution should be strongly considered as treatment for bacterial and chlamydial conjunctivitis, especially in developing countries where topical antibiotics are often unavailable or costly.