Anaesthesia
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Randomized Controlled Trial Clinical Trial Controlled Clinical Trial
The delivery of oxygen by a venturi T piece.
We have evaluated the performance of the Intersurgical 40% Oxygen Recovery T-Kit in ten healthy volunteers. Inspired oxygen and end-tidal carbon dioxide concentrations were measured during normal respiration and with variations in respiratory rate and depth. ⋯ All three modifications increased the inspired oxygen concentration, the longer expiratory limb to 34.6% (p < 0.01) and the altered T piece arrangement to 37.3% (p < 0.01). The highest inspired oxygen concentration of 40.3% (p < 0.01) was obtained by increasing the length of the inspiratory limb.
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
A comparison of the recovery characteristics of sevoflurane and halothane in children.
The recovery characteristics of sevoflurane and halothane anaesthesia were compared in 40 children aged 6 months to 6 years undergoing day case surgery. The mean time taken to open eyes after surgery had ended was appreciably and significantly shorter after sevoflurane than after halothane (sevoflurane, mean time (SD) 7 min 52 s (5 min 46 s), halothane, mean time (SD) 15 min 50 s (9 min 2 s), t = 3.32, p = 0.002). ⋯ However, more children were in pain and given analgesia after sevoflurane (p < 0.01) and the mean time to reach the criteria for discharge home was similar in both groups (sevoflurane, mean time (SD) 2 h 9 min (17 min), halothane, mean time (SD) 2 h 4 min (8 min)). There were no major complications in either group.
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
A comparison of the induction characteristics of sevoflurane and halothane in children.
The induction characteristics of sevoflurane and halothane were compared in 81 children aged 6 months to 6 years. The mean time taken to achieve loss of eyelash reflex was significantly shorter with sevoflurane than with halothane (sevoflurane, mean time (SD) 1 min 41 s (35 s), halothane, mean time (SD) 2 min 17 s (43 s), t = 4.11, p = < 0.01). ⋯ Effects on heart rate, blood pressure and oxygen saturation during induction were similar for both agents. There were no major complications during induction with either halothane or sevoflurane.
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Randomized Controlled Trial Comparative Study Clinical Trial
Infusions of subhypnotic doses of propofol for the prevention of postoperative nausea and vomiting.
We studied the antiemetic effects of a low dose infusion of propofol for 24 h after major gynaecological surgery in a double-blind, randomised, controlled trial. Fifty women of ASA physical status 1 or 2 undergoing major gynaecological surgery received an infusion of 1% propofol or intralipid at 0.1 ml.kg-1.h-1 for 24 h after surgery. Pain was managed using morphine delivered by a patient-controlled analgesia pump. ⋯ There were no differences between the two groups in any of the measures of postoperative nausea and vomiting during the first 48 h after surgery. Postoperative nausea and vomiting in the control group was less on the second day compared with the first postoperative day, but not in the propofol group. There were no side effects from the propofol infusion.
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Randomized Controlled Trial Comparative Study Clinical Trial
A comparison of the effects of isoflurane and desflurane on the neuromuscular effects of mivacurium.
The effects of 1 MAC of desflurane and isoflurane (in 66% nitrous oxide) on the potency and duration of action of mivacurium were studied in 80 patients. The ED95 of mivacurium was 86 micrograms.kg-1 (74-100) and 88 micrograms.kg-1 (76-103) (mean and 95% confidence intervals) during anaesthesia with desflurane and isoflurane respectively. ⋯ There was no significant difference in any of the variables between desflurane and isoflurane. It is concluded that the neuromuscular effects of mivacurium are similar during anaesthesia with 1 MAC of desflurane and isoflurane.