Anaesthesia
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Randomized Controlled Trial Clinical Trial
The influence of epidural administration of fentanyl infusion on gastric emptying in labour.
The effect of epidural infusions containing fentanyl on maternal gastric emptying in labour was examined using the rate of paracetamol absorption. Women were randomly allocated to receive one of two epidural infusions, bupivacaine 0.125% alone or bupivacaine 0.0625% with fentanyl 2.5 micrograms.ml-1 at a rate of 10-12 ml.h-1. Paracetamol 1.5 g was given orally to women after either 30 ml of the infusion solution had been given (mean time 2.5 h, study A) or 40-50 ml (mean time 4.5 h. study B). ⋯ There were no significant differences in maximum plasma paracetamol concentration, time to maximum paracetamol concentration and area under the concentration-time curve between the two groups for study A. In study B the time to maximum plasma paracetamol concentration was significantly delayed in women receiving > 100 micrograms fentanyl compared with controls (p < 0.05). We conclude that the dose of fentanyl that may delay gastric emptying when given by epidural infusion is greater than 100 micrograms.
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Acute intra-operative collapse of a lobe without apparent cause is rare. We report a case of transient bilobar atelectasis that developed without any apparent cause after a difficult tracheal intubation in a healthy young patient. ⋯ The characteristics of the lung collapse were atypical, suggesting either its reflex nature or acute reduction of lung volume owing to intubation-induced coughing. We present a review of the mechanisms of atelectasis.
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We describe the loss of function in the sciatic nerve after an uneventful sciatic nerve block using 25 ml of lignocaine 1% with adrenaline 1 in 200,000 in a patient receiving beta blocker drugs. Lack of pain on injection and complete regeneration of the nerve after 12 months in a patient with severe peripheral vascular disease led us to postulate ischaemic nerve damage as a mechanism of injury. Adrenaline-induced unopposed alpha-mediated vasoconstriction in a beta-blocked patient is suggested as a possible mechanism of peripheral nerve injury worthy of further investigation.
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The long-term survival of elderly patients following critical illness in the United Kingdom has not previously been studied. The demographic (age, sex, diagnosis, severity of illness) and treatment details (admission type, length of treatment, prior surgery) of all critically ill patients aged over 70 years were recorded. The 1-year survival of such patients was measured and compared with that of a matched normal population. ⋯ The 1-year survival of patients aged < 85 years was 56% which was significantly better than that of patients over 85 years (27%). The survival of all critically ill elderly patients was significantly poorer than that of a matched normal population (1-year survival 93%). Logistic regression revealed that age, diagnosis and severity of illness are independent predictors of 1-year survival.