American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Oct 2012
Meta AnalysisGenome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.
Genome-wide association studies (GWAS) have identified loci influencing lung function, but fewer genes influencing chronic obstructive pulmonary disease (COPD) are known. ⋯ These results suggest an important role for the CHRNA5/3 region as a genetic risk factor for airflow obstruction that may be independent of smoking and implicate the HTR4 gene in the etiology of airflow obstruction.