American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Oct 2012
Multicenter StudyEarly intensive care sedation predicts long-term mortality in ventilated critically ill patients.
Choice and intensity of early (first 48 h) sedation may affect short- and long-term outcome. ⋯ Early sedation depth independently predicts delayed extubation and increased mortality, making it a potential target for interventional studies.
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Am. J. Respir. Crit. Care Med. · Oct 2012
Randomized Controlled Trial Multicenter StudyEfficacy of antibiotic therapy for acute exacerbations of mild to moderate chronic obstructive pulmonary disease.
Antimicrobial therapy remains a controversial issue in nonsevere exacerbations of chronic obstructive pulmonary disease (COPD). ⋯ Treatment of ambulatory exacerbations of mild-to-moderate COPD with amoxicillin/clavulanate is more effective and significantly prolongs the time to the next exacerbation compared with placebo.
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Am. J. Respir. Crit. Care Med. · Oct 2012
Multicenter StudyEndobronchial ultrasound skills and tasks assessment tool: assessing the validity evidence for a test of endobronchial ultrasound-guided transbronchial needle aspiration operator skill.
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is becoming standard of care for the sampling of mediastinal adenopathy. The need for a safe, effective, accurate procedure makes EBUS-TBNA ideal for mastery training and testing. ⋯ The EBUS-STAT can be used to reliably and objectively score and classify EBUS-TBNA operators from novice to expert. Its use to assess and document the acquisition of knowledge and skill is a step toward the goal of mastery training in EBUS-TBNA.
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Am. J. Respir. Crit. Care Med. · Oct 2012
Multicenter StudyImpact of intensive care unit organ failures on mortality during the five years after a critical illness.
The relationship between organ failure during critical illness and long-term survival is uncertain, especially among intensive care unit (ICU) survivors. ⋯ Cardiovascular, respiratory, and liver failures during critical illness strongly predict subsequent 5-year survival. Acute organ failure burden is associated with long-term mortality even among patients who survive up to 1 year after ICU admission.