American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Sep 2014
Multicenter Study Comparative StudyMulticenter Development and Validation of a Risk Stratification Tool for Ward Patients.
Most ward risk scores were created using subjective opinion in individual hospitals and only use vital signs. ⋯ We developed an accurate ward risk stratification tool using commonly collected electronic health record variables in a large multicenter dataset. Further study is needed to determine whether implementation in real-time would improve patient outcomes.
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Am. J. Respir. Crit. Care Med. · Sep 2014
Comparative StudyThe Relationship between Hospital Volume and Mortality in Severe Sepsis.
Severe sepsis is increasing in incidence and has a high rate of inpatient mortality. Hospitals that treat a larger number of patients with severe sepsis may offer a survival advantage. ⋯ Patients with severe sepsis treated in hospitals with higher case volumes had improved adjusted outcomes.
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Am. J. Respir. Crit. Care Med. · Sep 2014
Comment Letter Case ReportsIn-Flight Pneumothorax: Diagnosis May Be Missed because of Symptom Delay.
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Am. J. Respir. Crit. Care Med. · Sep 2014
Squalene Synthase Induces TNFR1 Enrichment in Lipid Rafts to Promote Lung Cancer Metastasis.
Metabolic alterations contribute to cancer development and progression. However, the molecular mechanisms relating metabolism to cancer metastasis remain largely unknown. ⋯ Up-regulation of SQS promotes metastasis of lung cancer by enhancing tumor necrosis factor-α receptor 1 and nuclear factor-κB activation and matrix metallopeptidase 1 expression. Targeting SQS may have considerable potential as a novel therapeutic strategy to treat metastatic lung cancer.