American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Sep 2014
Randomized Controlled Trial Multicenter Study Comparative StudyA Functional Synonymous Coding Variant in the IL1RN Gene Associates with Survival in Septic Shock.
Death from infection is a highly heritable trait, yet there are few genetic variants with known mechanism influencing survival during septic shock. ⋯ In European ancestry subjects, the IL1RN variant rs315952C is preferentially transcribed and associated with increased evoked plasma IL1RA and with improved survival from septic shock. It may be that genetically determined IL1RA levels influence survival from septic shock.
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Am. J. Respir. Crit. Care Med. · Sep 2014
Randomized Controlled TrialRandomized Controlled Trial of Calcitriol in Severe Sepsis.
Vitamin D and its metabolites have potent immunomodulatory effects in vitro, including up-regulation of cathelicidin, a critical antimicrobial protein. ⋯ Calcitriol administration did not increase plasma cathelicidin protein levels in critically ill patients with sepsis and had mixed effects on other immunomodulatory markers. Additional phase II trials investigating the dose and timing of calcitriol as a therapeutic agent in specific sepsis phenotypes may be warranted. Clinical trial registered with www.clinicaltrials.gov (NCT 01689441).